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Polymorphisms in DNA damage binding protein 2 (DDB2) and susceptibility of primary lung cancer in the Chinese: a

Zhibin Hu1, Minhua Shao, Jing Yuan

  • 1Department of Epidemiology and Biostatistics, Cancer Research Center of Nanjing Medical University, Nanjing 210029, China.

Carcinogenesis
|March 9, 2006
PubMed

Insights

Common variants in the DNA damage binding protein 2 (DDB2) gene, specifically the rs830083 polymorphism, are linked to an increased risk of lung cancer. This genetic factor may play a role in lung cancer development, particularly in heavy smokers.

Area of Science:

  • Genetics
  • Molecular Biology
  • Cancer Research

Background:

  • DNA damage binding protein 2 (DDB2) is crucial for nucleotide excision repair (NER), a pathway involved in repairing DNA damage caused by carcinogens like tobacco smoke.
  • Deficiencies in NER capacity are associated with increased lung cancer risk.
  • Mutations in DDB2 can lead to xeroderma pigmentosum group E, highlighting its role in DNA repair.

Purpose of the Study:

  • To investigate the association between common variants in the DDB2 gene and the risk of developing lung cancer.
  • To determine if specific single nucleotide polymorphisms (SNPs) in DDB2 correlate with lung cancer susceptibility.

Main Methods:

  • A case-control study was conducted with 1010 lung cancer patients and 1011 cancer-free controls.
  • Two DDB2 SNPs, rs830083 and rs3781620, were genotyped.
  • Statistical analysis was performed to assess the risk associated with different genotypes.

Main Results:

  • Carrying the heterozygous rs830083CG genotype was associated with a 1.31-fold increased risk of lung cancer compared to the CC genotype.
  • The homozygous rs830083GG genotype showed a non-significant 1.22-fold elevated risk.
  • The association between DDB2 rs830083 variants and lung cancer risk was more pronounced in younger individuals, heavy smokers, and those with a family history of cancer.

Conclusions:

  • The DDB2 rs830083 polymorphism is potentially a novel genetic factor contributing to lung cancer etiology.
  • These findings suggest that variations in DNA repair genes like DDB2 can influence an individual's susceptibility to lung cancer.
  • Further functional studies are recommended to elucidate the molecular mechanisms underlying this association.

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