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Acquired extroversion associated with bitemporal variant of frontotemporal dementia
Mario F Mendez1, Andrew K Chen, Jill S Shapira
1Department of Neurology, University of California Los Angeles, Los Angeles, CA 90073, USA. mmendez@ucla.edu
The Journal of Neuropsychiatry and Clinical Neurosciences
|March 10, 2006
Summary
Frontotemporal dementia (FTD) can cause personality changes like acquired extroversion. This study links bitemporal FTD to extroversion, suggesting specific brain damage patterns influence personality shifts.
Area of Science:
- Neuroscience
- Psychiatry
- Neurology
Background:
- Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by prominent personality and behavioral changes.
- The specific alterations in personality are often linked to the precise location of neuropathology within the brain.
Observation:
- This study details three patients who developed acquired extroversion and met diagnostic criteria for FTD.
- Functional neuroimaging revealed predominant bilateral temporal lobe involvement in all three cases.
Findings:
- Acquired extroversion in bitemporal FTD may stem from damage to bilateral amygdala, leading to reduced fear or threat perception.
- Damage to orbitofrontal-ventromedial regions could cause social disinhibition.
- Preserved dorsolateral frontal and anterior cingulate regions might maintain interpersonal agency.
Implications:
- FTD serves as a valuable model for understanding the neurobiological underpinnings of personality dimensions, particularly introversion and extroversion.
- Investigating FTD-related personality changes offers insights into the complex relationship between brain structure and individual character traits.
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