Related Experiment Video
Updated: Aug 10, 2026

Model of Ischemia and Reperfusion Injury in Rabbits
Published on: November 3, 2023
[The role of ischemic preconditioning in acute myocardial infarction]
Andelka Ristić1, Milorad Damjanović, Branislav Baskot
1Vojnomedicinska akademija, Beograd, Klinika za urgentnu internu medicinu.
Introduction:
Ischemic preconditioning is a phenomenon in which brief episodes of ischemia and reperfusion increase myocardial tolerance and substantially reduce the infarction size.
Case Report:
Two patients with acute left anterior descending artery occlusion received fibrinolytic therapy within 6 hours of symptom onset, but nevertheless developed myocardial infarctions of different size. The first patient, without a history of preinfarction angina, developed a large anterior infarction, because there was no time for ischemic preconditioning or development of coronary collateral vessels. The second patient, with a 4-day history of preinfarction angina, had a more favorable outcome - he developed apical necrosis, with greater myocardial viability in the infarct-related area.
Conclusion:
The beneficial effects of angina occurring 24-48h before infarction are resulting from ischemic preconditioning, which reduces cardiac mortality, infarct size and occurrence of life-threatening ventricular arrhythmias.
Related Concept Videos
Acute Coronary Syndrome IV: Interprofessional Care
Acute Coronary Syndrome I: Introduction
Ischemic Stroke ll: Pathophysiology
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Ischemic Stroke l: Introduction

