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Hypersalivation in temporal lobe epilepsy.

Jagdish Shah1, Huifang Zhai, Darren Fuerst

  • 1Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

Epilepsia
|March 15, 2006
PubMed
Summary
This summary is machine-generated.

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Increased salivation during seizures often indicates the non-dominant temporal lobe origin in temporal lobe epilepsy (TLE). This finding helps in lateralizing seizure onset and can resolve after surgery.

Area of Science:

  • Neurology
  • Epileptology
  • Clinical Neuroscience

Background:

  • Temporal lobe epilepsy (TLE) presents with various clinical signs aiding in seizure onset lateralization.
  • Ictal hypersalivation is an infrequently reported manifestation of partial epilepsy.

Purpose of the Study:

  • To investigate if hypersalivation can help lateralize seizure onset in complex partial seizures originating from the temporal lobe.
  • To assess the clinical significance of ictal hypersalivation in TLE.

Main Methods:

  • Reviewed 10 patients with prominent ictal hypersalivation during complex partial seizures.
  • Utilized video-electroencephalography (EEG) monitoring, Wada testing, MRI, and FDG-PET scans.
  • Correlated hypersalivation with seizure origin and surgical outcomes.

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Main Results:

  • Seven of 10 patients had nondominant (right) TLE; three had dominant (left) TLE.
  • All patients showed hippocampal atrophy on MRI.
  • Eight surgically treated patients achieved seizure freedom (Engel class I) with resolution of hypersalivation.

Conclusions:

  • Prominent ictal hypersalivation in complex partial seizures is likely associated with nondominant temporal lobe origin.
  • Surgical intervention for TLE with hypersalivation leads to seizure freedom and symptom resolution.
  • Larger studies are required to confirm these findings.