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Updated: Aug 10, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
Published on: June 11, 2015
Comparative and functional genomics of closteroviruses
Valerian V Dolja1, Jan F Kreuze, Jari P T Valkonen
1Department of Botany and Plant Pathology and Center for Genome Research and Biocomputing, Oregon State University, Corvallis, OR 97331, USA. doljav@science.oregonstate.edu
Large RNA viruses, like Coronaviridae and Closteroviridae, show conserved gene modules for RNA replication and particle assembly. Their complex genomes evolve through diverse mechanisms, mirroring genomic evolution in other life forms.
Area of Science:
- Virology
- Molecular Biology
- Evolutionary Biology
Background:
- The largest RNA genomes are found in Coronaviridae (animal viruses) and Closteroviridae (plant viruses).
- Comparative analysis of Closteroviridae reveals distinct gene conservation levels.
Purpose of the Study:
- To analyze gene conservation and evolutionary patterns within the Closteroviridae family.
- To understand the genomic complexity and evolution of large RNA viruses.
Main Methods:
- Comparative genomic analysis of Closteroviridae.
- Identification of conserved gene modules and variable gene functions.
- Analysis of protein domains and homology.
Main Results:
- A conserved RNA replication module is shared with other virus families.
- A five-gene module for particle assembly and transport is characteristic of Closteroviridae.
- Variable genes include RNA silencing suppressors, proteases, and RNA repair proteins.
Conclusions:
- Closteroviridae genomes exhibit a modular structure with conserved and variable components.
- Evolutionary processes shaping these genomes are complex and dynamic.
- Genomic fluidity in large RNA viruses may share mechanisms with broader evolutionary processes in life.
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