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Bioengineered teeth from tooth bud cells.

Pamela C Yelick1, Joseph P Vacanti

  • 1Department of Cytokine Biology, The Forsyth Institute, Boston, MA 02115, USA. pyelick@forsyth.org

Dental Clinics of North America
|March 15, 2006
PubMed
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Tissue engineering is advancing hard and soft tissue repair, showing promise for dental applications. Research is focusing on creating bioengineered dental tissues and whole teeth for clinical use.

Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Dental tissue engineering

Background:

  • Tissue engineering and materials science have significantly advanced hard and soft tissue repair.
  • Successful applications of tissue engineering in bioengineering dental tissues are being demonstrated.
  • The regeneration of dental tissues and whole teeth using tissue engineering is a growing possibility.

Purpose of the Study:

  • To explore the potential of tissue engineering for dental tissue repair and regeneration.
  • To direct the formation of bioengineered dental tissues and whole teeth with specific size and shape.
  • To assess the clinical relevance of tooth tissue engineering.

Main Methods:

  • Utilizing advances in dental progenitor cell characterization.

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  • Employing improved methods for fabricating biodegradable scaffold materials.
  • Focusing on directing the formation of specific dental tissue structures.

    • Main Results:

    • Tissue engineering has shown successful applications in bioengineering dental tissues.
    • The ability to engineer dental tissues and whole teeth is progressing.
    • Current efforts are directed towards controlling the size and shape of engineered dental tissues.

    Conclusions:

    • Tissue engineering holds significant promise for dental tissue repair and regeneration.
    • Advances in progenitor cells and scaffold materials are key to clinical translation.
    • Tooth tissue engineering is moving closer to becoming a clinically relevant practice.