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Updated: Aug 10, 2026

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
Published on: August 4, 2021
Endotracheal delivery of medications during neonatal resuscitation
Myra H Wyckoff1, Jonathan Wyllie
1Department of Pediatrics, Division of Neonatal/Perinatal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX 75290-9063, USA. myra.wyckoff@utsouthwestern.edu
Abstract:
If the endotracheal route is to be used for administration of epinephrine, the limited available evidence suggests that the currently recommended dose of 0.01 mg/kg is likely to be too low to be effective. Given the paucity of high-quality clinical data regarding endotracheal epinephrine, the intravenous route should be used as soon as venous access is established. Given the complete lack of clinical data in newborns, endotracheal administration of naloxone is not recommended.
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