Relationship between serum prostate-specific antigen and prostate volume in Korean men with benign prostatic...

Area of Science:

• Urology
• Andrology
• Medical Diagnostics

Background:

• Prostate volume (PV) is crucial for managing benign prostatic hyperplasia (BPH).
• Prostate specific antigen (PSA) is explored as a non-invasive proxy for estimating PV.
• Existing data on the PSA-PV relationship primarily focuses on Caucasian populations.

Purpose of the Study:

• To evaluate the relationship between PSA and PV in Korean men with BPH.
• To determine if PSA can serve as a reliable estimator of PV in this demographic.
• To establish age-specific PSA thresholds for predicting PV in Korean men.

Main Methods:

• A multicentre study included 5716 Korean men aged 50-79 with LUTS and BPH.
• Exclusion criteria included high PSA levels (>10 ng/mL) to minimize cancer risk.
• Receiver operating characteristic (ROC) curves analyzed PSA's predictive ability for PV thresholds (30, 40, 50 mL).

Main Results:

• A log-linear, age-dependent relationship was observed between PSA and PV.
• PSA demonstrated good predictive value for various prostate volume thresholds.
• The strength of the PSA-PV relationship increased with age.

Conclusions:

• The PSA-PV relationship in Korean men mirrors that in Caucasians.
• Korean men generally exhibit lower PSA levels and smaller PVs compared to Caucasians.
• Age-specific PSA criteria were proposed for identifying Korean men with PV >40 mL.