Related Experiment Video
Updated: Aug 10, 2026

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
Published on: January 24, 2025
Topical microbicides: the time has come
Darpun Dhawan1, Marla Keller, Mary E Klotman
1Division of Infectious Disease, Mount Sinai School of Medicine, New York, USA.
Abstract:
Microbicides are vaginally or rectally applied drugs that inhibit HIV and other sexually transmitted pathogens. About 30 microbicidal products are being studied in preclinical and clinical trials. Data from in vitro, animal, and in vivo investigations with candidate microbicidal compounds support a proof of concept, although large-scale clinical trials will determine efficacy. Because there are multiple targets for HIV infection in the genital tract, synergistic combinations of microbicides will probably offer the greatest protection for non-HIV-infected persons and might decrease transmissibility when used by those infected with HIV.
Related Concept Videos
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Microbial Corrosion
Microorganisms in Medicine and Therapeutics
Clinical Significance of Antibiotic Resistance
Antimicrobial Effectiveness
The Skin Microbiota
