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Updated: Jul 31, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
[Tumor necrosis factor blocking agents: a review. Part I: Clinical efficacy evaluation]
C Rodríguez Moreno1, P López Vázquez, C Durán Parrondo
1Servicios de Farmacología Clínica, Complexo Hospitalario Universitario, Santiago de Compostela, a Coruña, Spain. carlos.rodríguez.moreno@sergas.es
Abstract:
Blockade of tumor necrosis factor with monoclonal antibodies, has emerged as one of the most promising therapies in some autoimmune conditions as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and Crohn s disease. They have shown effectiveness on reducing symptoms and modifying the progression of the disease. However, they disrupt the balance of inflammatory and immune responses and some risks associated with TNF-blockers have become apparent. The purpose of this article is to review the evidence about benefits and risk associated with the use of TNF-blockers in approved indications and to provide practical recommendations for its use in the management of these conditions.
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