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A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
Published on: January 6, 2023
Silica, silicosis, and lung cancer
Alon Peretz1, Harvey Checkoway, Joel D Kaufman
1Department of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, Washington 98105, USA. alonpe@u.washington.edu
Abstract:
Evidence that crystalline silica is associated with an increased rate of lung cancer led the International Agency for Research on Cancer to conclude in 1997 that crystalline silica is a known human carcinogen. In Israel too, crystalline silica is considered as such. The decision raised a debate in the scientific arena, and a few scientists have questioned the basis upon which causality was determined. We review the literature regarding the level of evidence of crystalline silica carcinogenicity.
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