Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Recurrent herpetic keratitis in mice].

K Mitsui1

  • 1Department of Ophthalmology, Yokohama City University School of Medicine, Japan.

Nippon Ganka Gakkai Zasshi
|June 1, 1991
PubMed
Summary

Mice spontaneously develop recurrent herpetic keratitis after initial infection with herpes simplex virus (HSV). This establishes a viable animal model for studying the mechanisms of recurrent epithelial keratitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment Strategies and Effectiveness in Lymphatic Malformations: A 10-Year Retrospective Study.

Lymphology·2025
Same author

Assessment of the potential for pathogen dispersal during high-flow nasal therapy.

The Journal of hospital infection·2019
Same author

Removal methods of rigid stylets to minimise adverse force and tracheal tube movement: a mathematical and in-vitro analysis in manikins.

Anaesthesia·2019
Same author

Translocator protein 18kDa antagonist ameliorates stress-induced stool abnormality and abdominal pain in rodent stress models.

Neurogastroenterology and motility·2018
Same author

Comparative study of 27-gauge vs 25-gauge vitrectomy for epiretinal membrane.

Eye (London, England)·2016
Same author

The effects of Patent Blue dye on peripheral and cerebral oxyhaemoglobin saturations.

Anaesthesia·2014

Area of Science:

  • Ophthalmology
  • Virology
  • Immunology

Context:

  • Herpes simplex keratitis (HSK) recurrence poses a significant clinical challenge.
  • Understanding HSK recurrence mechanisms requires a reliable animal model.
  • Previous models have limitations in spontaneous recurrence observation.

Purpose:

  • To establish and validate a mouse model for spontaneous recurrent epithelial keratitis.
  • To observe the occurrence and characteristics of recurrent HSK in mice.
  • To detect herpes simplex virus (HSV) presence during recurrence.

Summary:

  • Mice infected with herpes simplex virus (HSV) type I were monitored for spontaneous recurrent epithelial keratitis.
  • Recurrent lesions, characterized by punctate or dendritic patterns, were observed in both C57BL/6 and ddy mouse strains.
  • HSV antigen was detected in the corneal epithelium of recurrently affected eyes, confirming viral involvement.

Impact:

  • This study successfully establishes a mouse model for spontaneous recurrent herpetic keratitis.
  • The model provides a platform for investigating the underlying mechanisms of HSK recurrence.
  • Findings facilitate the development of novel therapeutic strategies for HSK.

Related Experiment Videos