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Generation of the Early-Gestational Maternal Immune Activation Mouse Model to Assess Prenatal Inflammation on Neurodevelopment
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Generation of the Early-Gestational Maternal Immune Activation Mouse Model to Assess Prenatal Inflammation on Neurodevelopment

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[A, M and G immunoglobulins during premature pregnancy]

D G Tevdorashvili, G G Tevdorashvili, N G Kurashvili

    Georgian Medical News
    |April 1, 2006
    PubMed

    Immunological process develops as a result of the failure of mechanisms providing the state of conditional tolerance of maternal immune system in regard to antigens of feto-placental complex. Immune response is mainly directed towards maintenance of internal homeostasis of maternal organism in critical conditions, and as a result interruption of pregnancy takes occurs. Development of pregnancy leads to more expressed decrease of T-cellular indices, as well as of humoral immunity. The state of immunodeficiency increases vulnerability of woman organism to damaging agents, what, in its turn, promotes development of immunopathological process.

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