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[Abdominal malignancies in childhood].

M W Ben Arush1, M Peretz-Nahum, J A Bar Maor

  • 1Pediatric Surgery Dept., Rambam Medical Center, Haifa.

Harefuah
|May 1, 1991
PubMed
Summary

Pediatric abdominal tumors (AT) in children are diagnosed at a younger age than other solid tumors (ST). Improved treatment protocols since 1981 have significantly increased survival rates for AT, particularly Burkitt lymphoma and Wilms' tumor.

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Area of Science:

  • Pediatric oncology
  • Epidemiology of childhood cancers
  • Tumor biology

Context:

  • Review of 134 pediatric abdominal tumors (AT) out of 460 solid tumors (ST) diagnosed between 1971-1989.
  • Analysis of epidemiological data and treatment outcomes for children with AT.
  • Comparison of patient demographics and tumor characteristics between AT and ST groups.

Purpose:

  • To analyze the epidemiological features and outcomes of pediatric abdominal tumors.
  • To evaluate the impact of therapeutic advancements on survival rates for AT.
  • To identify trends in the incidence of specific AT subtypes, such as abdominal Burkitt lymphoma.

Summary:

  • Pediatric abdominal tumors present in younger children compared to other solid tumors.
  • Burkitt lymphoma, Wilms' tumor, and neuroblastoma are the most common histologic types of AT.
  • A significant improvement in 5-year actuarial survival was observed for AT patients treated after 1981 (71.1%) compared to those treated before 1981 (32.8%).
  • Survival rates approach 80% for Wilms' tumor and abdominal Burkitt lymphoma treated since 1981.

Impact:

  • Demonstrates a substantial improvement in survival for pediatric abdominal tumors due to therapeutic changes.
  • Highlights the effectiveness of modern treatment protocols for specific pediatric abdominal malignancies.
  • Provides valuable data for understanding the epidemiology and prognosis of childhood abdominal cancers.

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