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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Anti-HCV in post-transfusion hepatitis: deductions from a prospective study
S V Feinman1, B Berris, R Herst
1Department of Medicine, Mount Sinai Hospital, Toronto, Canada.
Journal of Hepatology
|May 1, 1991
Summary
Hepatitis C virus (HCV) antibody testing in post-transfusion hepatitis (PTH) revealed that while most acute PTH cases may not be HCV-related, those progressing to chronic hepatitis are often caused by HCV.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Post-transfusion hepatitis (PTH) poses a significant clinical challenge.
- Hepatitis C virus (HCV) is a primary cause of viral hepatitis.
Purpose of the Study:
- To investigate the role of anti-HCV antibodies in patients who developed post-transfusion hepatitis (PTH).
- To determine the association between anti-HCV seroconversion and hepatitis outcomes.
Main Methods:
- Sera from patients with PTH, their blood donors, and patients with chronic hepatitis were tested for anti-HCV.
- Alanine aminotransferase (ALT) levels were monitored during acute hepatitis phases.
Main Results:
- Anti-HCV seroconversion was observed in patients with PTH, with earlier conversion linked to higher ALT values.
- Only 9% of resolved hepatitis cases showed anti-HCV, compared to 61% of chronic hepatitis cases.
- HCV antibody-positive donors transmitted hepatitis, leading to chronic disease in some recipients.
Conclusions:
- Anti-HCV-positive donors can transmit hepatitis C.
- Most acute PTH cases may not be HCV-related or involve undetectable anti-HCV.
- HCV is the likely cause of PTH that progresses to chronic hepatitis.
