Related Experiment Video

Updated: Aug 9, 2026

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
07:07

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice

Published on: June 27, 2020

Clinical features of influenza C virus infection in children

Yoko Matsuzaki1, Noriko Katsushima, Yukio Nagai

  • 1Department of Infectious Diseases, Yamagata University School of Medicine, Iida-Nishi, Yamagata, Japan. matuzaki@med.id.yamagata-u.ac.jp

The Journal of Infectious Diseases
|April 6, 2006
PubMed

Insights

Influenza C virus commonly causes upper respiratory illness in young children. Infants under two years old face a higher risk of severe complications, including lower respiratory tract infections like pneumonia.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Respiratory Illness

Background:

  • Influenza C virus is globally prevalent but poorly understood due to isolation challenges.
  • Limited clinical data exists for influenza C virus infections.

Purpose of the Study:

  • To investigate the clinical features of influenza C virus infection in children.
  • To identify risk factors for severe outcomes.

Main Methods:

  • Analysis of clinical data from 170 children infected with influenza C virus.
  • Specimens collected from pediatric patients aged 15 years or younger between 1990 and 2004.

Main Results:

  • Most infections (92.4%) occurred in children under 6 years old.
  • Common symptoms included fever (90.0%), cough (74.1%), and rhinorrhea (61.8%).
  • Hospitalization rates were higher in children under 2 years old (30.4%) compared to those aged 2-5 (11.9%), with lower respiratory tract illness being common.

Conclusions:

  • Influenza C virus is a significant cause of upper respiratory tract illness in children under 6.
  • Infants under 2 years old have a heightened risk of lower respiratory tract complications.
Abstract

More Related Videos

Rapid Molecular Detection and Differentiation of Influenza Viruses A and B05:38

Rapid Molecular Detection and Differentiation of Influenza Viruses A and B

Published on: January 30, 2017

Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause: