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Related Experiment Videos

Fibrates.

R Robillard1, C Fontaine, G Chinetti

  • 1UR545 INSERM, Département d'Athérosclérose, Institut Pasteur, Lille, France.

Handbook of Experimental Pharmacology
|April 7, 2006
PubMed
Summary
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Fibrates, hypolipidemic drugs, reduce atherosclerosis progression by activating peroxisome-proliferator activated receptor-alpha. These drugs also offer anti-inflammatory benefits, impacting the development of atherosclerosis.

Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Molecular Biology

Background:

  • Atherosclerosis of large arteries is a primary cause of cerebro- and cardiovascular diseases.
  • The pathophysiology of coronary and cerebrovascular atherosclerosis is complex and multifactorial.
  • Hypolipidemic drugs, such as fibrates, are used to manage lipid levels and cardiovascular risk.

Purpose of the Study:

  • To review the multifaceted effects of fibrates on atherosclerosis development.
  • To highlight the role of fibrates in modulating lipid metabolism and inflammation.
  • To explore the mechanism of action of fibrates via peroxisome-proliferator activated receptor-alpha (PPAR-α) activation.

Main Methods:

  • Literature review of studies on fibrate therapy and atherosclerosis.

Related Experiment Videos

  • Analysis of preclinical and clinical data on fibrate's impact on atherosclerotic lesions.
  • Examination of the molecular pathways influenced by fibrates, particularly PPAR-α signaling.

    • Main Results:

    • Fibrates effectively lower triglyceride levels and modestly increase HDL cholesterol.
    • Activation of PPAR-α by fibrates leads to reduced expression of inflammatory genes in vascular cells.
    • Fibrates have demonstrated a capacity to slow the progression of atherosclerotic lesions in various vascular beds.

    Conclusions:

    • Fibrates represent a significant therapeutic option for managing atherosclerosis.
    • The pleiotropic effects of fibrates, beyond lipid-lowering, contribute to their atheroprotective properties.
    • Targeting PPAR-α with fibrates offers a promising strategy to combat cardiovascular disease progression.