Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stabilizers and destabilizers controlling cell cycle oscillators.

Daniele Guardavaccaro1, Michele Pagano

  • 1Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.

Molecular Cell
|April 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma.

Developmental cell·2026
Same author

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System.

bioRxiv : the preprint server for biology·2026
Same author

The E3-ome gene-centric compendium reveals the human E3 ligase landscape.

Cell·2026
Same author

GMCL1 controls 53BP1 stability and modulates taxane sensitivity.

eLife·2026
Same author

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation.

Cell communication and signaling : CCS·2025
Same author

The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells.

Molecular cell·2025

Destabilizing factors in the ubiquitin system regulate cell cycle progression by fine-tuning cyclin-dependent kinases (CDKs). Hierarchical waves of cyclin stabilizers reveal the intricate network controlling cell cycle timing.

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Molecular Biology

Background:

  • The cell cycle clock ensures precise and ordered progression through cell division.
  • The ubiquitin system plays a critical role in regulating protein degradation and cellular processes.
  • Cyclin-dependent kinases (CDKs) are key regulators of cell cycle transitions.

Purpose of the Study:

  • To elucidate the role of ubiquitin system destabilizing factors in cell cycle clock regulation.
  • To investigate how these factors contribute to the synchrony and unidirectionality of the cell cycle.
  • To understand the implications of cyclin stabilizer waves in this regulatory network.

Main Methods:

  • Analysis of ubiquitin-protein ligase activity.
  • Biochemical assays to measure CDK activity.

Related Experiment Videos

  • Cellular imaging to observe cyclin dynamics.

    • Main Results:

    • Destabilizing factors of the ubiquitin system were identified as crucial modulators of CDK activity.
    • These factors contribute to the precise timing and unidirectional progression of the cell cycle.
    • Hierarchical and interconnected waves of cyclin stabilizers were observed, demonstrating network complexity.

    Conclusions:

    • The ubiquitin system's destabilizing factors are essential for maintaining cell cycle clock integrity.
    • Fine-tuning of CDK activity by these factors ensures accurate cell cycle progression.
    • The complex network of cyclin stabilizers underscores the sophisticated regulation of cell division.