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Experimental cerebral vasospasm and cyclic adenosine monophosphate (c-AMP)
Investigative Radiology
|May 1, 1975
Summary
Aminophylline reversed acute cerebral vasospasm in monkeys. Chronic vasospasm required Aminophylline plus Isoproterenol, suggesting cyclic AMP (c-AMP) pathways are key to vascular smooth muscle reactivity.
Area of Science:
- Neurology
- Pharmacology
- Vascular Biology
Background:
- Cerebral vasospasm, a narrowing of brain arteries, can follow bleeding.
- Understanding vasospasm mechanisms is crucial for effective treatment.
Purpose of the Study:
- To investigate the effects of vasoactive agents on acute and chronic cerebral vasospasm.
- To explore the role of cyclic adenosine monophosphate (c-AMP) in cerebral vasospasm.
Main Methods:
- Serial angiography was used to monitor cerebral vasospasm in Rhesus monkeys.
- Two vasoactive agents, Aminophylline and Isoproterenol, were administered to induce and reverse vasospasm.
Main Results:
- Aminophylline effectively reversed acute, blood-induced cerebral vasospasm.
- Chronic vasospasm reversal required both Aminophylline and Isoproterenol.
- Results suggest a link between intracellular c-AMP levels and vascular smooth muscle response.
Conclusions:
- Cerebral vasospasm may involve decreased intracellular c-AMP in vascular smooth muscle.
- Pharmacological manipulation of the c-AMP pathway can reverse cerebral vasospasm.
- c-AMP appears to be a central pathway for mediating adrenergic vascular reactivity.