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Updated: Aug 9, 2026
13:13
Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
S100B protein related neonatal hypoxia
Régis Osorio Martins1, Newra Telechea Rotta, Luiz V Portela
1r.o.martins@terra.com.br
Arquivos De Neuro-Psiquiatria
|April 20, 2006
Summary
S100B protein is a key marker for assessing neonatal asphyxia in newborns with hypoxic-ischemic encephalopathy. This study found a significant correlation between S100B protein and lactate levels, highlighting their combined diagnostic value.
Area of Science:
- Neonatal Medicine
- Biochemistry
- Neurology
Background:
- Biochemical markers are crucial for evaluating neonatal asphyxia.
- S100B protein is a significant marker in this research area.
Purpose of the Study:
- To emphasize the role of S100B protein in assessing term newborns with hypoxic-ischemic encephalopathy.
- To correlate S100B protein levels with other substances involved in ischemia.
Main Methods:
- Studied 21 term newborns with hypoxic-ischemic encephalopathy from Sept 2003 to Oct 2004.
- Collected samples on days 1 and 4 of life.
- Measured S100B protein and lactate concentrations using immune cytochemistry.
Main Results:
- A positive relationship was observed between S100B protein and lactate levels.
- A statistically significant correlation was found between these two substances.
Conclusions:
- S100B protein is important in assessing hypoxic-ischemic encephalopathy in newborns.
- S100B protein and lactate are significantly correlated, suggesting combined diagnostic utility.
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