Related Experiment Video

Updated: Aug 9, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
06:59

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

Glucose metabolism in non-diabetic patients with stable coronary artery disease

José Ferreira Santos1, Manuel Almeida, Jorge Ferreira

  • 1Serviço de Cardiologia, Hospital de Santa Cruz, Carnaxide, Portugal. jferreirasantos@netvisao.pt

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|April 21, 2006
PubMed

Insights

Many coronary artery disease (CAD) patients have undiagnosed impaired glucose metabolism (IGM), including prediabetes and diabetes. Early identification of IGM in CAD patients is crucial for managing cardiovascular risk.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Coronary artery disease (CAD) patients may have undiagnosed impaired glucose metabolism (IGM), even with normal fasting glucose.
  • Undiagnosed IGM is linked to a higher risk of cardiovascular events.

Purpose of the Study:

  • To determine the prevalence of IGM in CAD patients without diagnosed diabetes.
  • To evaluate the impact of IGM on the cardiovascular risk profile of these patients.

Main Methods:

  • Oral glucose tolerance test (OGTT) was used to diagnose IGM in 54 CAD patients without prior diabetes history.
  • Patients were categorized into normal glucose tolerance, prediabetes, and diabetes groups.
  • Cardiovascular risk factors, including lipid profile, insulin resistance, and A1c, were analyzed.

Main Results:

  • Impaired glucose metabolism (IGM) was found in 69% of patients, with 43% having prediabetes and 26% having diabetes.
  • IGM patients exhibited more dyslipidemia, higher triglycerides and urea, and lower HDL cholesterol.
  • Metabolic syndrome and more severe (multivessel) CAD were significantly more prevalent in patients with IGM.

Conclusions:

  • Routine OGTT in CAD patients without diabetes can detect a substantial number with prediabetes or diabetes.
  • Identifying and managing IGM in CAD patients is essential for improving cardiovascular risk profiles.
Abstract

Related Concept Videos

Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose Homeostasis: Regulation of Blood Glucose01:02

Glucose Homeostasis: Regulation of Blood Glucose

Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...