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Updated: Aug 9, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Facile synthesis of mono-, di-, and trisubstituted alpha-unbranched hydrazines
1The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. lars@kemiker.dk
Abstract:
Methods for the alkylation of di-tert-butyl hydrazine-1,2-dicarboxylate were investigated. It was found that under mild conditions mono- or di-substituted hydrazine derivatives were obtained in good to excellent yield. Furthermore, it was shown that one of the two Boc-groups of the disubstituted derivatives was selectively removed by heating, leading to precursors for trisubstituted hydrazines.
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