Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Packaging00:58

DNA Packaging

94.7K
Overview
94.7K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

12.2K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
12.2K
Nucleosome Remodeling02:54

Nucleosome Remodeling

8.8K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
8.8K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

22.5K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
22.5K
Duplication of Chromatin Structure02:05

Duplication of Chromatin Structure

6.1K
The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...
6.1K
The Nucleosome Core Particle01:12

The Nucleosome Core Particle

2.6K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nucleotide resolution 4-thiouridine sequencing by SNU-Seq and sf4sU-Seq reveals the transcriptional responsiveness of an epigenetically primed human genome.

Nucleic acids research·2026
Same author

A targeted metabolomic method to detect epigenetically relevant metabolites.

Molecular metabolism·2026
Same author

Metabolite accumulation mediates the shift between the High Oxygen Consumption and Low Oxygen Consumption phases in the Yeast Metabolic Cycle.

bioRxiv : the preprint server for biology·2026
Same author

Paradigm Lost.

Cancers·2025
Same author

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.

Molecular metabolism·2024
Same author

Gene transcription in yeasts: From molecules to integrated processes.

Yeast (Chichester, England)·2024
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
See all related articles

Related Experiment Video

Updated: May 5, 2026

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging
09:52

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Published on: January 31, 2019

10.7K

Dynamic nucleosomes and gene transcription.

Jane Mellor1

  • 1Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. jane.mellor@bioch.ox.ac.uk

Trends in Genetics : TIG
|April 25, 2006
PubMed
Summary
This summary is machine-generated.

Gene transcription relies on dynamic chromatin, involving DNA and histone codes. This study explores dynamic nucleosomes and histone codes for gene regulation.

More Related Videos

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

2.1K
Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

5.5K

Related Experiment Videos

Last Updated: May 5, 2026

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging
09:52

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Published on: January 31, 2019

10.7K
Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

2.1K
Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

5.5K

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genetics

Background:

  • Gene transcription occurs on chromatin, a dynamic nucleosomal template.
  • Transcriptional regulation involves DNA genetic codes and histone epigenetic codes.
  • Chromatin is not static; it undergoes dynamic changes influencing gene expression.

Purpose of the Study:

  • To explore new concepts of dynamic nucleosomes in gene transcription.
  • To investigate the role of a dynamic histone code in regulating gene expression.
  • To understand the interplay of factors affecting chromatin states and transcription.

Main Methods:

  • Literature review and conceptual exploration of existing data.
  • Analysis of dynamic processes within the nucleosome structure.
  • Integration of genetic and epigenetic regulatory mechanisms.

Main Results:

  • Chromatin is a highly dynamic environment, not a stable structure.
  • Histones, regulatory proteins, and enzymes are in constant flux.
  • Factors cooperate or compete to alter chromatin states, affecting transcription.

Conclusions:

  • Dynamic nucleosomes and a dynamic histone code are crucial for gene transcription.
  • Understanding these dynamics is key to comprehending gene activation and repression.
  • This framework offers new insights into gene regulation mechanisms.