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Prevention and treatment of corneal graft rejection: current practice patterns (2004)
J Bradley Randleman1, R Doyle Stulting
1Department of Ophthalmology, Emory University, Atlanta, GA, USA. Jrandle@emory.edu
Cornea
|April 25, 2006
Summary
Topical prednisolone is the primary treatment for corneal graft rejection. Newer agents like loteprednol etabonate and topical cyclosporine are increasingly used for prevention and treatment in corneal transplantation.
Area of Science:
- Ophthalmology
- Transplantation Immunology
Background:
- Corneal graft rejection remains a significant challenge in transplantation.
- Understanding current treatment protocols is crucial for optimizing patient outcomes.
Purpose of the Study:
- To analyze contemporary practices in preventing and treating corneal graft rejection.
- To compare current management strategies with historical data.
Main Methods:
- A survey was distributed in January 2004 to members of The Cornea Society.
- The survey focused on postoperative management and rejection treatment protocols for corneal transplants.
Main Results:
- Topical corticosteroids, primarily prednisolone, are universally used for routine management and rejection treatment.
- Loteprednol etabonate and topical cyclosporine show expanding use, particularly in high-risk cases.
- A decrease in oral and subconjunctival steroid use was observed compared to previous practices.
Conclusions:
- Topical prednisolone remains the standard of care for corneal graft rejection.
- Emerging agents like loteprednol etabonate and topical cyclosporine are gaining traction in clinical practice.
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