Related Experiment Video
Updated: Aug 9, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Relationship between ciliary blood flow and aqueous production: does it play a role in glaucoma therapy?
Jeffrey W Kiel1, Herbert A Reitsamer
1Department of Ophthalmology, University of Texas Health Science Center, San Antonio, TX 78229, USA. kiel@uthscsa.edu
Abstract:
This review will summarize the authors' recent studies of the relationship between ciliary blood flow and aqueous production, and discuss the relevance of that relationship to the mechanisms of action of glaucoma drugs that lower intraocular pressure by inhibiting aqueous production. The ciliary processes are not easily accessible, and so the data presented necessarily come from animals and from instrumentation operated at its engineering limits. Verification of the findings in humans, and perhaps refinement of the interpretations, must await future advances in technology. Nonetheless, the results to date are intriguing, and may help explain some paradoxes in glaucoma pharmacology.
Related Concept Videos
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
Ophthalmic Drug Delivery Systems
Microbiome of the Eye