Related Experiment Video
Updated: Aug 9, 2026
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
[Maxipime in the treatment of neonatal sepsis]
Abstract:
The aim of our work was to confirm the effectiveness of the IV generation cephalosporin maxipime. Patients with sepsis, septicaemia (induced by enterobacter cloacae) were investigated. We utilized several antibiotics of large spectrum of action, but the situation was stabilized and improved after the initiation of maxipime. Stabilization of the intestinal peristaltic has been achieved using the nutritional mixture alfare (Nestle). Alfare totally satisfies child's demands on vitamins and microelements. Maxipime should be recommended to be included in the formulae of antibiotics at the pediatric intensive care units. Maxipime is the effective and safe antibiotic and has very good results in the cases of childhood sepsis with severe course, including septic shock and pollyorganic insufficiency.
Insights
Maxipime, an IV cephalosporin antibiotic, effectively treats severe childhood sepsis, including septic shock. Its use in pediatric intensive care units is recommended for improved patient outcomes.
Area of Science:
- Infectious Diseases
- Pediatric Critical Care
- Pharmacology
Background:
- Sepsis and septicemia pose significant threats in pediatric intensive care.
- Enterobacter cloacae is a common pathogen in severe pediatric infections.
- Effective antibiotic therapy is crucial for managing life-threatening sepsis.
Purpose of the Study:
- To evaluate the efficacy of intravenous (IV) generation cephalosporin, maxipime, in treating pediatric sepsis.
- To assess maxipime's effectiveness in cases of severe sepsis, septic shock, and multiple organ dysfunction.
- To determine if maxipime should be a standard antibiotic in pediatric intensive care units.
Main Methods:
- Investigated pediatric patients diagnosed with sepsis and septicemia.
- Administered broad-spectrum antibiotics, including maxipime.
- Utilized the nutritional mixture alfare for supportive care to stabilize intestinal peristalsis.
Main Results:
- Maxipime demonstrated effectiveness in stabilizing and improving patients with severe sepsis.
- Patients treated with maxipime showed positive responses, even in critical conditions like septic shock.
- Alfare nutritional mixture aided in stabilizing intestinal function, meeting nutritional needs.
Conclusions:
- Maxipime is an effective and safe antibiotic for treating severe childhood sepsis.
- The study recommends incorporating maxipime into antibiotic protocols for pediatric intensive care units.
- Maxipime shows promising results in managing complex pediatric sepsis cases with severe outcomes.
