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Intra-individual variability of high-sensitivity C-reactive protein: age-related variations over time in Japanese
Ali Nasermoaddeli1, Michikazu Sekine, Sadanobu Kagamimori
1Department of Welfare Promotion and Epidemiology, Faculty of Medicine, University of Toyama, Toyama, Japan. moaddeli@ms.toyama-mpu.ac.jp
Insights
High-sensitivity C-reactive protein (hsCRP) levels show significant within-subject variation over time in both men and women. This variability differs by age, potentially impacting cardiovascular disease risk assessment.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Epidemiology
Background:
- Prospective studies link baseline high-sensitivity C-reactive protein (hsCRP) levels to cardiovascular disease (CVD) risk.
- Understanding the variability of hsCRP over time is crucial for accurate risk assessment.
Purpose of the Study:
- To investigate the repeatability of hsCRP measurements in men and women.
- To examine how age influences hsCRP variability.
Main Methods:
- Measurements of hsCRP were taken from 899 men and 780 women (aged 18-60) in 2004 and 2005.
- Within-subject repeatability and intra-class correlation coefficients were used to assess measurement variation.
- Analytical variance was found to be negligible, indicating measurement process reliability.
Main Results:
- A substantial within-subject variation in hsCRP was observed (reliability coefficient 0.61).
- Repeatability coefficients were 5.25 in men and 5.38 in women.
- Age influenced variation, with less variation noted in women over 40.
Conclusions:
- Single hsCRP measurements exhibit considerable within-subject variation in both sexes.
- This variation differs across age groups, particularly in women.
- HsCRP variability may impact the assessment of future cardiovascular event risk.
Background:
Prospective studies have demonstrated a direct association between the baseline level of high-sensitivity C-reactive protein (hsCRP) and the risk of developing cardiovascular disease. The potential for hsCRP variability during the follow-up interval is of great interest, so the repeatability of measurements of hsCRP in men and women, and in different age groups, was investigated in the present study.
Methods And Results:
The measurement of hsCRP was performed in 899 male and 780 female Japanese civil servants aged 18-60 years in the spring of 2004 and 2005. Within-subject repeatability and intra-class correlation coefficient of reliability were used to characterize the variation in measurements. Error of the measurement process was negligible, as the analytical variance was 0.0003 [ln(mg/L)] [ln(mg/L)] with a reliability coefficient of 0.997. In contrast, the within-subject variation of hsCRP was considerable with a reliability coefficient of 0.61 in both sexes and repeatability coefficients of 5.25 and 5.38 in men and women, respectively. The variation differed with age, especially in women, as less variation was observed in subjects over 40 years of age during the follow-up interval.
Conclusions:
The results suggest that a single measurement of hsCRP is subject to considerable but equal within-subject variation over time in men and women, and this variation differs among the age groups, which may affect the risk assessment of hsCRP in association with future cardiovascular events.
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