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Related Experiment Videos

Soft tissue sarcoma with complex membranous and microtubular inclusions.

J E Szakacs1, G Kasnic, A K Walling

  • 1Pathology Service, H. Lee Moffitt Cancer Center, Tampa, FL 33682.

Annals of Clinical and Laboratory Science
|November 11, 1991
PubMed
Summary

Complex cytoplasmic inclusions, including microtubular reticular structure (TRS) and tubular confronting cisternae (TCC), were found in a rare undifferentiated sarcoma. Their biological significance in this tumor remains unclear.

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Area of Science:

  • Cell Biology
  • Pathology
  • Electron Microscopy

Background:

  • Undifferentiated sarcomas can exhibit complex cytoplasmic inclusions.
  • Certain inclusions like microtubular reticular structure (TRS) and tubular confronting cisternae (TCC) are associated with specific viral infections and autoimmune diseases.

Observation:

  • A 67-year-old woman's undifferentiated sarcoma, originating in paraspinal adipose tissue, displayed complex cytoplasmic inclusions in most tumor cells.
  • Four distinct morphologic types of inclusions were identified: intracisternal TRS and TCC, and cytoplasmic crystalline microtubular arrays and smooth endoplasmic reticulum (SER) complexes.
  • The smooth endoplasmic reticulum (SER) inclusions were uniquely complex, differing from previously described structures.

Findings:

  • The observed inclusions included intracisternal microtubular reticular structure (TRS) and tubular confronting cisternae (TCC).

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  • Cytoplasmic inclusions consisted of crystalline microtubular arrays and complex smooth endoplasmic reticulum (SER) structures.
  • The patient had no known conditions typically associated with TRS and TCC, such as lupus or viral infections.

    • Implications:

    • The presence of these complex inclusions in sarcoma, without typical associated pathologies, presents a novel finding in tumor biology.
    • Further research is needed to elucidate the formation, function, and biological significance of these unique cytoplasmic structures in mesenchymal tumors.
    • This case highlights the diverse and sometimes unexpected ultrastructural features that can arise in neoplastic cells.