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Cerebral perfusion response to hyperoxia.

Daniel P Bulte1, Peter A Chiarelli, Richard G Wise

  • 1FMRIB Centre, Department of Clinical Neurology, University of Oxford, Oxford, UK. bulte@fmrib.ox.ac.uk

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|May 4, 2006
PubMed
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Supplemental oxygen can be used for noninvasive magnetic resonance imaging (MRI) contrast. Mild reductions in brain perfusion were observed at moderate hyperoxia levels, supporting its use for blood flow and volume measurements.

Area of Science:

  • Radiology
  • Medical Imaging
  • Physiology

Background:

  • Hyperoxia is a potential blood oxygenation level-dependent contrast agent for MRI.
  • High oxygen levels may decrease brain perfusion, complicating blood flow and volume measurements.
  • The hyperoxic range between normoxia and 100% oxygen is understudied.

Purpose of the Study:

  • To investigate graded levels of supplemental inspired oxygen for noninvasive intravascular MRI contrast.
  • To assess the effects of hyperoxia on regional brain perfusion.

Main Methods:

  • Subjects received graded levels of hyperoxia during a single session.
  • Perfusion was measured using arterial spin labelling MRI.
  • Regional grey matter perfusion was analyzed.

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Main Results:

  • Reductions in regional grey matter perfusion occurred at moderate hyperoxia levels.
  • Perfusion changes were mild (less than 10%) across all tested oxygen levels.
  • These findings support the viability of hyperoxia-induced contrast.

Conclusions:

  • Graded hyperoxia is a viable noninvasive method for intravascular MRI contrast.
  • Mild perfusion changes at moderate hyperoxia levels do not preclude its use for blood flow and volume assessment.