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Updated: Aug 8, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Lectin binding to mouse blood lymphocytes during tumor growth
S M Sitdikova1, B S Amandzholov, M V Kiselevskii
1N. N. Blokhin National Oncological Research Center, Russian Academy of Medical Sciences, Moscow.
Abstract:
Binding of FITC-labeled lectins to lymphocytes from intact mice and mice with transplanted Ehrlich carcinoma and CaO-1 ovarian carcinoma was studied by flow cytofluorometry. Specific binding of lectins by mannose and N-acetylgalactosamine was demonstrated. Lectin binding to lymphocytes from animals with tumors decreased by more than 50% in comparison with intact animals. Changed protein glycosylation during tumor growth is specific and differs for tumors of different origin.
