Related Experiment Videos

Cardiac arrest associated with febrile illness due to U.K. acquired Cyclospora cayetanensis

Christopher Burrell1, Srinivasulu Reddy, Guy Haywood

  • 1Department of Cardiology, Southwest Cardiothoracic Centre, Derriford Hospital, Plymouth PL6 8DH, UK. chris.burrell@phnt.swest.nhs.uk

Insights

A rare Cyclospora cayetanensis infection caused fever and diarrhea, leading to cardiac arrest in a UK man. This case highlights the potential link between febrile illnesses and fatal ventricular arrhythmias.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Clinical Medicine

Background:

  • Cyclospora cayetanensis is an intestinal pathogen causing gastrointestinal illness.
  • Febrile illnesses can precipitate cardiac events, particularly ventricular arrhythmias.

Observation:

  • A 43-year-old man with UK-acquired Cyclospora cayetanensis infection developed fever and diarrhea.
  • During his febrile illness, he experienced an out-of-hospital cardiac arrest.

Findings:

  • Extensive cardiac investigations, including echocardiogram, coronary angiogram, and electrophysiological studies, did not reveal an underlying cardiac cause.
  • The case suggests a potential association between Cyclospora infection-induced fever and cardiac arrest.

Implications:

  • Clinicians should consider the possibility of severe cardiac dysrhythmias in patients with febrile illnesses, even without known cardiac conditions.
  • This case underscores the importance of recognizing potential triggers for ventricular arrhythmias during infections.

Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...