[Genetic diagnosis of acute leukemias--a practical guide]

Acute leukemias are the consequence of accumulation of immature precursor cells. Genetic alterations are cause of uncontrolled cell proliferation. They can be detected by conventional cytogenetics and molecular methods at diagnosis. Classification of acute leukemias according to the World Health Organization depend on the knowledge of the presence of these aberrations. Furthemore they are important prognostic parameters influencing therapy intensity. Genetic abnormalities can be targets of novel therapeutic strategies. Detection and monitoring of genetic abnormalities in acute leukemias are of major importance for correct management of patients.