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[Hepatitis by infectious mononucleosis].

V Albornoz1, E Wainstein, A Andrade

  • 1Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Santiago.

Revista Medica De Chile
|October 1, 1991
PubMed
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Infectious mononucleosis (IM) can present as acute hepatitis in adults. Blood smear examination is crucial for diagnosing IM-induced hepatitis by identifying atypical lymphocytes.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Hematology

Background:

  • Acute hepatitis necessitates a broad differential diagnosis.
  • Infectious mononucleosis (IM) is a common viral illness often caused by Epstein-Barr virus (EBV).
  • Hepatitis is a recognized, though less common, manifestation of IM.

Observation:

  • Five adult patients presented with symptoms of acute hepatitis.
  • Clinical signs included malaise, prolonged fever, hepatomegaly, and jaundice.
  • Laboratory findings revealed elevated aminotransferases and hyperbilirubinemia.

Findings:

  • Peripheral blood smear examination was critical, revealing atypical lymphocytes (Downey cells).
  • Diagnosis of IM was confirmed by serological tests for EBV-specific antibodies (IgM) or heterophil antibodies.

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  • Associated findings included lymphadenopathy and splenomegaly.

    • Implications:

    • Highlights the importance of considering IM in the differential diagnosis of acute hepatitis in adults.
    • Emphasizes the diagnostic utility of peripheral blood smear analysis in identifying atypical lymphocytes.
    • Suggests that early diagnosis of IM-induced hepatitis can guide appropriate patient management.