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The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
Published on: November 2, 2016
Angiogenesis: from plants to blood vessels
Tai-Ping Fan1, Ju-Ching Yeh, Kar Wah Leung
1Angiogenesis and Traditional Chinese Medicine Laboratory, Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK. tpf1000@cam.ac.uk
Trends in Pharmacological Sciences
|May 16, 2006
Summary
Plant-derived compounds offer promising avenues for improving angiotherapy, the treatment of diseases involving blood vessel formation. Traditional Chinese medicine
Area of Science:
- Vascular biology and pharmacology
- Natural product drug discovery
- Integrative medicine
Background:
- Angiogenesis is a critical pathological process in diseases like cancer and coronary heart disease.
- Current therapeutic strategies for angiogenesis require safer and more effective approaches.
- Traditional Chinese Medicine (TCM) has utilized plant-derived compounds for angiotherapy for millennia.
Purpose of the Study:
- To explore the potential of plant-derived compounds in developing novel angiotherapy treatments.
- To highlight the role of Traditional Chinese Medicine (TCM) in identifying proangiogenic and antiangiogenic agents.
- To emphasize the need for evidence-based research and chemical optimization of TCM formulations (fufang) for enhanced therapeutic efficacy.
Main Methods:
- Review of existing literature on plant-derived compounds and angiogenesis.
- Analysis of Traditional Chinese Medicine (TCM) principles and practices in treating angiogenesis-related diseases.
- Exploration of combination therapy concepts in both Western medicine and TCM (fufang).
Main Results:
- Plant-derived compounds possess significant proangiogenic and antiangiogenic properties.
- TCM formulations (fufang) represent a sophisticated approach to combination therapy, maximizing efficacy and minimizing toxicity.
- Existing research suggests a strong foundation for developing evidence-based plant-based medicines for angiotherapy.
Conclusions:
- Plant-derived compounds hold substantial promise for advancing angiotherapy.
- Further research and chemical optimization of TCM-derived fufang are crucial for realizing their full therapeutic potential.
- Integrating TCM knowledge with modern scientific approaches can lead to safer and more effective treatments for angiogenesis-related pathologies.
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