[Experimental study of heavy metal interactions in mice]

The aim of the study was the evaluation of behaviour of mice after long exposure to compounds of lead, cadmium and zinc. Behaviour of animals in the following tests was observed: motor coordination, cognitive activity, spontaneous motility, motility in a straight rod test. Influence of the investigated compounds on the body temperature of experimental animals was determined. By analyzing dependence dose-effect and the time of exposure disorders on motor coordination and cognitive activity were observed. Cumulative administration of compounds of lead, cadmium and zinc did not cause important disorders in spontaneous motility and body temperature in mice. Transmission disorders in the nervous system following administration of maximal doses of lead and cadmium may be the result of cumulative action of these compounds in the body. However, the absence of this effect in minimal doses is probably the result of antagonistic action of zinc.