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Updated: Aug 8, 2026
09:14
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Pathogenic link between hydroa vacciniforme and Epstein-Barr virus-associated hematologic disorders
Keiji Iwatsuki1, Masataka Satoh, Takenobu Yamamoto
1Departments of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Archives of Dermatology
|May 17, 2006
Summary
Latent Epstein-Barr virus (EBV) infections are linked to hydroa vacciniforme (HV) and severe HV-like eruptions. Severe cases involve EBV-associated T-cell lymphoproliferative disorders and can be fatal.
Area of Science:
- Dermatology
- Virology
- Immunology
Background:
- Hydroa vacciniforme (HV) is a rare photodermatosis.
- The role of Epstein-Barr virus (EBV) in HV pathogenesis is not fully understood.
Purpose of the Study:
- To investigate the association between latent EBV infections and typical and severe HV-like eruptions.
- To analyze complications and outcomes in patients with HV.
Main Methods:
- Case series of 29 patients with HV or severe HV-like eruptions.
- In situ hybridization and immunostaining of biopsy specimens.
- EBV DNA assays on cutaneous lesions and peripheral blood mononuclear cells.
Main Results:
- EBV-encoded small nuclear RNA (EBER)-positive T cells were found in 97% of patients.
- Severe HV cases showed increased EBV DNA, NK-cell lymphocytosis, and complications like hemophagocytic syndrome.
- Five severe cases died from EBV-associated lymphomas or hemophagocytic syndrome.
Conclusions:
- Typical and severe HV are part of a spectrum of EBV-infected T-cell mediated cutaneous disorders.
- Severe HV may represent overt EBV-associated NK/T-cell lymphoproliferative disorders with a poor prognosis.
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