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Altered expression of the Smad signalling pathway: implications for COPD pathogenesis

A Zandvoort1, D S Postma, M R Jonker

  • 1Dept of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

The European Respiratory Journal
|May 19, 2006
PubMed
Summary

Chronic obstructive pulmonary disease (COPD) involves aberrant transforming growth factor-beta-Smad pathway signaling, leading to reduced decorin production and altered extracellular matrix in emphysema. This impacts tissue repair and fibrosis in COPD patients.

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