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Aprotinin in the management of coagulopathy associated with amniotic fluid embolus

Jeffrey Stroup1, Davin Haraway, J Martin Beal

  • 1University of Oklahoma College of Pharamcy, Tulsa, 74135, USA. Jeffrey-Stroup@ouhsc.edu

Pharmacotherapy
|May 24, 2006
PubMed

Amniotic fluid embolus, also known as anaphylactoid syndrome of pregnancy is a rare complication of pregnancy. When it occurs, the maternal mortality rate may be as high as 86%, and in survivors, the morbidity rate may be just as high. Hallmark clinical features include maternal cardiovascular collapse with disseminated intravascular coagulation, and fetal distress. Management centers on strategies to improve oxygenation, support circulation, and correct the coagulopathy. We report the case of a patient who developed amniotic fluid embolus and was effectively managed with aprotinin to control the coagulopathy associated with this devastating complication of pregnancy.

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