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Updated: Aug 8, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Easy access to the family of thiazole N-oxides using HOF x CH3CN
1School of Chemistry, Tel-Aviv University, Tel-Aviv, Israel 69978.
Abstract:
An efficient procedure for transferring an oxygen atom to thiazole-containing compounds, resulting in the corresponding N-oxides, was developed by using HOF x CH3CN; mild reaction conditions, high yields and easy purification are the main features of this novel route, while X-ray structural analysis reveals a hydrogen bond between the N-oxide functionality and a water molecule.
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