Related Experiment Video
Updated: Aug 8, 2026

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy
Published on: September 20, 2024
Recognition and management of pediatric seizures
Steven M Wolf1, Patricia Engel McGoldrick
1Epilepsy Monitoring Unit, Beth Israel Medical Center, New York, NY, USA. stwolf@chpnet.org
Insights
Primary care providers should understand epilepsy comorbidities and anti-epileptic drugs. Children with intractable epilepsy may need referral to specialized centers for advanced treatments like the ketogenic diet or surgery.
Area of Science:
- Pediatric Neurology
- Epilepsy Management
Background:
- Primary care providers (PCPs) often encounter children with unexplained paroxysmal events or skin lesions.
- While pediatric neurologists manage most epilepsy cases, PCPs need foundational knowledge.
Purpose of the Study:
- To highlight the importance of PCP understanding of epilepsy comorbidities.
- To inform PCPs about anti-epileptic drugs (AEDs), side effects, and monitoring.
- To outline criteria for referring children with intractable epilepsy to specialized centers.
Main Methods:
- Review of current clinical practices and literature regarding pediatric epilepsy management.
- Discussion of common comorbidities associated with childhood epilepsy.
- Overview of available anti-epileptic medications and their adverse effects.
Main Results:
- PCPs play a crucial role in initial assessment and management of potential epilepsy cases.
- Adequate knowledge of AEDs, their side effects, and monitoring is essential for PCPs.
- Intractable epilepsy, defined as failure to control seizures with three or more appropriately dosed AEDs, necessitates specialist referral.
Conclusions:
- PCPs require comprehensive understanding of epilepsy to effectively manage or refer pediatric patients.
- Referral to comprehensive epilepsy centers offers advanced treatment options for intractable cases.
- Alternative therapies including ketogenic diet, vagal nerve stimulation, and epilepsy surgery should be considered for refractory epilepsy.
Abstract:
It is not unusual for the primary care provider to have a child present with unusual paroxysmal events or dermatological lesions that bear further investigation. Although most children with epilepsy are treated and managed by pediatric neurologists, it is imperative that the primary care provider have a clear understanding of associated comorbidities, as well as information on the available anti-epileptic drugs, their side effects, and the need for further monitoring. Those children with epilepsy whose seizures become intractable, failing to be controlled with three or more medications used appropriately at adequate doses, should be referred to a comprehensive epilepsy center for consideration for other treatments. These may include the ketogenic diet, vagal nerve stimulation, or epilepsy surgery.
More Related Videos
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
06:45Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Related Concept Videos
Seizures l: Introduction
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...