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Updated: Jul 20, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Evolving concepts in the pathogenesis of hairy-cell leukaemia
Enrico Tiacci1, Arcangelo Liso, Miguel Piris
1Institute of Haematology, University of Perugia, Italy. enrico.tiacci@uni-essen.de
Abstract:
Hairy-cell leukaemia (HCL) has long been recognized as distinct from other chronic B-cell malignancies, but several questions remain unanswered. What is the HCL cell of origin? Why does HCL lack the hallmarks of most mature B-cell tumours (for example, chromosomal translocations and consistent lymph node involvement) and show unique features like 'hairy' morphology and bone-marrow fibrosis? Gene-expression profiling and other studies have recently provided new insights into HCL biology and have the potential to affect clinical practice.
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