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CA 125: a potential tumor marker for gallbladder cancer
Amita Chaube1, Mallika Tewari, Usha Singh
1Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Journal of Surgical Oncology
|May 26, 2006
Summary
Cancer antigen 125 (CA 125) shows diagnostic potential for gallbladder carcinoma (GBC). This study demonstrates CA 125 can differentiate GBC from benign gallbladder diseases, aiding in diagnosis.
Area of Science:
- Oncology
- Biochemistry
- Clinical Diagnostics
Background:
- CA 125 is a known glycoprotein and tumor marker for ovarian carcinoma.
- Its diagnostic utility in gallbladder carcinoma (GBC) has not been previously reported.
- This study investigates the role of CA 125 in diagnosing gallbladder diseases.
Purpose of the Study:
- To evaluate the diagnostic accuracy of serum CA 125 levels in patients with GBC.
- To compare CA 125 levels between GBC, gallstone disease (GSD), and healthy controls.
- To assess the correlation of CA 125 with clinical and pathological parameters in GBC.
Main Methods:
- Serum CA 125 was measured using ELISA in 64 GBC patients, 47 GSD patients, and 23 healthy volunteers.
- Statistical analysis included Kruskal Wallis and Mann-Whitney tests for group comparisons.
- Receiver operating characteristic (ROC) curve analysis was performed to determine diagnostic utility.
Main Results:
- Significantly elevated CA 125 levels were observed in GBC patients (77.44 U/ml) compared to GSD (7.85 U/ml) and healthy controls (8.08 U/ml) (P < 0.001).
- At a cutoff of 11 U/ml, CA 125 demonstrated 64% sensitivity and 90% specificity in distinguishing GBC from benign gallbladder disease.
- CA 125 levels showed a trend of increase with GBC stage and grade, and were higher in patients with gallbladder mass, weight loss, ascites, and appetite loss.
Conclusions:
- Serum CA 125 possesses diagnostic potential for identifying gallbladder carcinoma.
- CA 125 can aid in differentiating malignant GBC from benign GSD when considered with other clinical information.
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