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Updated: Aug 8, 2026

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
Published on: September 14, 2021
[Functional interactions between the TGF-beta signaling pathway via the Smads and TNF-alpha: implications for the
1INSERM U697, Hôpital Saint-Louis, Pavillon Bazin, 1, avenue Claude Vellefaux, 75010 Paris. franck.verrecchia@stlouis.inserm.fr
Abstract:
The balance between production and degradation of type I collagen plays a critical role in the development and maintenance of organ and tissue integrity. Its also represents the most crucial element governing the process of tissue repair. TGF-beta, a key player in the physiopathology of tissue repair, enhances type I collagene gene expression. In contrast, TNF-alpha, whose matrix-remodelling function is opposite to that of TGF-beta, reduces type I collagen gene expression. This review focuses on transcriptional regulation of type I collagen by TGF-beta and TNF-alpha, and on the molecular mechanisms that control the antagonistic activity of TNF-alpha against TGF-beta-driven type I collagen gene expression.
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