[Functional interactions between the TGF-beta signaling pathway via the Smads and TNF-alpha: implications for the

Franck Verrecchia1

  • 1INSERM U697, Hôpital Saint-Louis, Pavillon Bazin, 1, avenue Claude Vellefaux, 75010 Paris. franck.verrecchia@stlouis.inserm.fr

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NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Regulation of Angiogenesis and Blood Supply

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Type IV Collagen of Basal Lamina

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A type IV collagen molecule has six alpha chains which can exist in...