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Keratitis due to Shigella flexneri.
Harry L Muytjens1, Catharina A Eggink, Frederik C A P Dijkman
1Department of Medical Microbiology, Nijmegen University Centre of Infectious Diseases, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Journal of Clinical Microbiology
|June 8, 2006
Summary
Multiresistant Shigella flexneri, a rare cause of ulcerative keratitis, was identified in a girl's cornea and stool. Genetic analysis confirmed identical isolates, highlighting the importance of recognizing this infection.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Shigella species are uncommon causes of ulcerative keratitis, with limited documented cases historically.
- Ulcerative keratitis can lead to severe vision impairment if not promptly treated.
Observation:
- Multiresistant Shigella flexneri strains were isolated from both the cornea and stool samples of a pediatric patient.
- Genetic sequencing confirmed that the Shigella isolates from the different body sites were identical.
Findings:
- This case represents one of the few documented instances of Shigella-induced ulcerative keratitis.
- The genetic identity of isolates suggests a potential systemic source or transmission route for the infection.
Implications:
- Early diagnosis and appropriate antimicrobial therapy are crucial for managing Shigella keratitis to prevent vision loss.
- This case underscores the need for considering atypical pathogens in severe ocular infections, even in the presence of systemic symptoms like shigellosis.