1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents
J A Lowe1, T F Seeger, A A Nagel
1Central Research Division, Pfizer, Inc., Groton, Connecticut 06340.
Abstract:
The design and synthesis of a series of potential atypical antipsychotic agents based on the structure of 1-naphthylpiperazine are described. The incorporation of dopamine antagonist activity into the parent structure was achieved with heterocyclic surrogates for the catechol moiety of dopamine. Compound 4b from this series showed a biochemical profile that translated to behavioral activity in the rat predictive of an antipsychotic agent with a low propensity to cause extrapyramidal side effects in man.
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