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Updated: Aug 7, 2026

The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
Surgical intervention in patients with moderate to severe pulmonary arterial hypertension
Omar A Minai1, Saiprakash B Venkateshiah, Alejandro C Arroliga
1Department of Pulmonary anc Critical Care Medicine, Cleveland Clinic Foundation, OH 44195, USA. minaio@ccf.org
Background:
Patients with pulmonary arterial hypertension are believed to experience severe postoperative complications after major surgery.
Methods:
We retrospectively analyzed the data of 21 patients with pulmonary arterial hypertension who underwent 28 surgical procedures at our institution between 1996 and 2002.
Results:
The average mean pulmonary arterial pressure was 53 +/- 14.4 mm Hg. Twenty-two procedures were performed under general anesthesia. Extubation occurred within 24 hours of surgery in 72% and an intensive care unit stay was not required after 43% of the procedures. Perioperative morbidity and mortality were typically related to the surgical procedure or underlying disease.
Conclusions:
In our study, patients with moderate to severe pulmonary arterial hypertension had an 18% per procedure mortality and a 19% rate of right heart failure after surgical intervention.
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