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Influence of azelastine on IL-1 beta generation in vitro and IL-1 beta-induced effect in vivo
U Werner1, J Schmidt, I Szelenyi
1Department of Pharmacology, ASTA Pharma AG, Frankfurt/Main, FRG.
Agents and Actions. Supplements
|January 1, 1991
Abstract:
The effects of the novel antiasthmatic/antiallergic compound azelastine on IL-1 beta were investigated in vitro and in vivo. In leukocytes both, intra- and extracellular IL-1 generation stimulated by LPS was inhibited dose dependently. In contrast azelastine did not prevent IL-1 beta-induced immigration of PMNs into the mouse ear. These findings suggest that azelastine is not an IL-1 antagonist but inhibits IL-1 synthesis and/or release in leukocytes.