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Pulmonary infiltration from chronic lymphocytic leukemia.
William Moore1, Daniel Baram, Youjun Hu
1Department of Radiology, Stony Brook University, Stony Brook, NY 11794, USA. William.Moore@stonybrook.edu
Journal of Thoracic Imaging
|June 14, 2006
Summary
Chronic lymphocytic leukemia can infiltrate the lungs, causing centrilobular nodularity visible on CT scans. This case series details imaging and pathology for this rare manifestation.
Area of Science:
- Pulmonology
- Oncology
- Radiology
Background:
- Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
- Pulmonary involvement in CLL is uncommon but can present with diverse imaging findings.
Observation:
- Two patients with CLL presented with respiratory symptoms.
- Computed tomography (CT) revealed centrilobular nodularity as a key finding.
Findings:
- Pathological examination confirmed leukemic infiltration of the lung parenchyma.
- Imaging patterns correlated with the extent and nature of the neoplastic involvement.
Implications:
- Recognizing these CT patterns aids in early diagnosis of pulmonary CLL.
- This highlights the importance of considering extranodal lymphoid infiltration in CLL patients with lung abnormalities.