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Updated: Aug 7, 2026

Gas Chromatography-Mass Spectrometry Paired with Total Vaporization Solid-Phase Microextraction as a Forensic Tool
Published on: May 25, 2021
Determination of volatile residual solvents in pharmaceutical products by headspace liquid-phase microextraction gas
Xia Wang1, Ting Jiang, Jinpeng Yuan
1Shandong Province Key Laboratory for Applied Technology of Sophisticated Analytical Instruments, Analysis and Test Center, Shandong Academy of Sciences, Jinan, Shandong 250014, People's Republic of China. xia-w21cn0@163.com
Abstract:
This paper demonstrates headspace liquid-phase microextraction (HS-LPME) as used for the determination of volatile residual solvents in pharmaceutical products. This method is based on headspace liquid-phase microextraction capillary column gas chromatography. Under optimum conditions, the linerary of the method ranged from 1 to 1,000 mg l(-1). The limits of detection are 0.2-6.0 [corrected] mg l(-1) and relative standard deviations (RSD) for most of the volatile solvents were below 10%. This novel method is applied to the analysis of volatile residual solvents in pharmaceutical products with satisfactory results.
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