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Histopathologic evaluation of alopecias.
Klaus Sellheyer1, Wilma F Bergfeld
1Departments of Dermatology and Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. sellhek@ccf.org
The American Journal of Dermatopathology
|June 17, 2006
Summary
This review details scarring and non-scarring alopecias, focusing on primary and secondary scarring types. It highlights histopathologic findings and clinical correlations for accurate alopecia diagnosis.
Area of Science:
- Dermatology
- Pathology
Background:
- Alopecia encompasses scarring and non-scarring forms.
- Scarring alopecias are further classified into primary and secondary types.
- Primary scarring alopecia directly targets the hair follicle, while secondary scarring alopecia involves adjacent non-follicular processes.
Purpose of the Study:
- To provide a comprehensive overview of alopecia classification.
- To detail the histopathologic features of major alopecia forms.
- To discuss pathogenetic concepts like stem cell failure in alopecia.
Main Methods:
- Review of existing literature on alopecia classification and histopathology.
- Detailed description of histopathologic presentations for various alopecias.
- Inclusion of clinical presentations for clinicopathologic correlation.
Main Results:
- Classification of alopecias into non-scarring and scarring (primary and secondary).
- Detailed histopathologic descriptions of major alopecia types.
- Discussion of pathogenetic mechanisms, including stem cell failure.
Conclusions:
- Accurate histopathologic diagnosis of alopecia requires clinicopathologic correlation.
- Understanding the distinct mechanisms of primary and secondary scarring alopecia is crucial.
- Stem cell failure is a significant pathogenetic concept in alopecia.